Anti-Insulin receptor (β subunit) Antibody (50104)

Host Quantity Applications Species Reactivity Data Sheet  
Mouse 100ug WB,IP,Inhibitor,Stimpulator,Activtion Human
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Overview
Product Name Anti-Insulin receptor (β subunit) Antibody (50104)
Description Anti-Insulin receptor Mouse Monoclonal Antibody
Target Insulin receptor (β subunit)
Species Reactivity Human
Applications WB,IP,Inhibitor,Stimpulator,Activtion
Host Mouse
Clonality Monoclonal
Clone ID 18-44
Isotype IgG2b
Immunogen Human placental insulin receptor
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by Protein G affinity chromatography
Specificity Information
Specificity All four clones recognize human insulin receptor; low-level cross-reactivity with bovine and rabbit insulin receptor.
Target Name Insulin receptor
Target ID Insulin receptor (β subunit)
Uniprot ID P06213
Alternative Names IR, EC 2.7.10.1, CD antigen CD220 [Cleaved into: Insulin receptor subunitα; Insulin receptor subunit β]
Gene Name INSR
Sequence Location Cell membrane, Late endosome, Lysosome
Biological Function Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically rUniProtKB:P15208, PubMed:12138094, PubMed:16314505, PubMed:16831875, PubMed:8257688, PubMed:8276809, PubMed:8452530, PubMed:9428692}.
Research Areas Growth Factors, Cytokines, Receptors
Application Images
Description All four clones recognize human insulin receptor; low-level cross-reactivity with bovine and rabbit insulin receptor.
Additional Information
Handling
Storage These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
References & Data Sheet
References Soos et al. (1986) Biochem J 235: 199
Brindle et al. (1990) Biochem J 268: 615
Prigent et al. (1990) J Biol Chem 265: 9970.