Catalog No.: 11005
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibit specific proteases. A novel member in the IAP protein family has been identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene. ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase- 9.
Antigen: Peptide corresponding to aa 2-13 of human ILP-2 (accession no. NP_203127).
Host Species: Rabbit
Preservatives: 0.02% sodium azide
This antibody recognizes human, mouse, and rat ILP-2 (33kDa).
Immunoblotting: use at 1ug/ml.
Immunocytochemistry: use at 10ug/ml.
Positive control: HepG2 or MOLT4 cell lysates.
These are recommended concentrations. Enduser should determine optimal concentrations for their applications.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.