Anti-CCR8 Antibody (2097)

Host Quantity Applications Species Reactivity Data Sheet  
Rabbit 100ug ELISA,WB Human
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Overview
Product Name Anti-CCR8 Antibody (2097)
Description Anti-CCR8 (EL) Rabbit Polyclonal Antibody
Target CCR8
Species Reactivity Human
Applications ELISA,WB
Host Rabbit
Clonality Polyclonal
Isotype IgG
Immunogen Peptide corresponding to aa 183-201 of human CCR8 which is located in the second extracellular loop.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by peptide immuno-affinity chromatography
Specificity Information
Specificity This antibody recognizes human CCR8 (50 kD).
Target Name C-C chemokine receptor type 8
Target ID CCR8
Uniprot ID P51685
Alternative Names C-C CKR-8, CC-CKR-8, CCR-8, CC chemokine receptor CHEMR1, CMKBRL2, Chemokine receptor-like 1, CKR-L1, GPR-CY6, GPRCY6, TER1, CD antigen CDw198
Gene Name CCR8
Gene ID 1237
Accession Number NP_005192
Sequence Location Cell membrane; Multi-pass membrane protein.
Biological Function Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. {PubMed:10540332, PubMed:9207005, PubMed:9469461, PubMed:9521068}.
Research Areas Infectious Disease
Background CCR8 is one of the chemokine receptors that are required as co- receptors for HIV infection. The genes encoding human and murine CCR8 have been cloned and designated TER1, CKR-L1, and ChemR1. The encoded seven transmembrane protein was identified as the receptor for human CC chemokine I-309 and renamed CCR8. Recently, CCR8 was found to serve as a coreceptor for diverse T-cell tropic, dual-tropic and macrophage- tropic HIV-1 strains. CCR8 mediates CC chemokine I-309 induced monocyte chemoattraction and HIV-1 envelope fusion and virus infection. CCR8 is expressed in spleen, thymus, and T lymphoblastic cell lines.
Application Images
Description Western blot analysis of CCR8 in human spleen lysate with CCR8 antibody at 1:500 dilution.
Additional Information
Handling
Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Dilution Instructions Dilute in PBS or medium which is identical to that used in the assay system.
Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution.

Positive control: Tissue lysate from human spleen.
References & Data Sheet