HIV Co-Receptor CCR8

Anti-CCR8 Antibody

ORDERING INFORMATION

Catalog No.: 2097
Size: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma-tography.

BACKGROUND

CCR8 is one of the chemokine receptors that are required as co- receptors for HIV infection. The genes encoding human and murine CCR8 have been cloned and designated TER1, CKR-L1, and ChemR1. The encoded seven transmembrane protein was identified as the receptor for human CC chemokine I-309 and renamed CCR8. Recently, CCR8 was found to serve as a coreceptor for diverse T-cell tropic, dual-tropic and macrophage- tropic HIV-1 strains. CCR8 mediates CC chemokine I-309 induced monocyte chemoattraction and HIV-1 envelope fusion and virus infection. CCR8 is expressed in spleen, thymus, and T lymphoblastic cell lines.

SPECIFICATION SUMMARY

Antigen: Peptide corresponding to aa 183-201 of human CCR8 which is located in the second extracellular loop.
Host Species: Rabbit
Stabilizers: None
Preservatives: 0.02% sodium azide.

SPECIFICITY

This antibody recognizes human CCR8 (50 kD).

APPLICATIONS

Immunoblotting: use at 1:500-1:1,000 dilution.
Positive control: Tissue lysate from human spleen.

DILUTION INSTRUCTIONS

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE AND STABILITY

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.