Anti-Bonzo (CT) Antibody (2415)

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	100ug	ELISA,WB,IHC-P	Human

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SKU: 2415 Categories: Antibody Products, Infectious Disease Antibodies, Products

Overview

Product Name Anti-Bonzo (CT) Antibody (2415)

Description Anti-Bonzo (CT) Rabbit Polyclonal Antibody

Target Bonzo (CT)

Species Reactivity Human

Applications ELISA,WB,IHC-P

Host Rabbit

Clonality Polyclonal

Isotype IgG

Immunogen Peptide corresponding to aa 319-338 at the C-terminus of human Bonzo. The sequence of this peptide is identical to those of macaque and African green monkey.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by peptide immuno-affinity chromatography

Specificity This antibody recognizes full-length Bonzo (40 kD).

Target Name C-X-C chemokine receptor type 6

Target ID Bonzo (CT)

Uniprot ID O00574

Alternative Names CXC-R6, CXCR-6, CDw186, G-protein coupled receptor STRL33, G-protein coupled receptor bonzo, CD antigen CD186

Gene Name CXCR6

Gene ID 10663

Accession Number NP_006555

Sequence Location Cell membrane; Multi-pass membrane protein.

Biological Function Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.

Research Areas Infectious Disease

Background Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) require coreceptors in addition to CD4 to infect target cells. Some G protein-coupled receptors in the chemokine receptor family, including CCR5, CXCR4, CCR3, and CCR2b, have previously been identified as HIV coreceptors. An orphan G protein- coupled receptor designated Bonzo was recently cloned and identified as a HIV- 1 and -2 and SIV coreceptor (also called STRL33 and TYMSTR). The messenger RNA for Bonzo is expressed in lymphoid tissues and activated peripheral blood lymphocytes.