Her2/Neu

Her2/Neu Monoclonal Antibody

ORDERING INFORMATION

Format: Purified antibody in Tris buffer, pH 7.3-7.7, 1% BSA, <0.1% sodium azide.

BACKGROUND

The Her2/Neu (c-erB-2) proto-oncogene product is a trans-membrane receptor tyrosine kinase that is clinically indicated in a number of carcinomas. Overexpression of the Her2/Neu protein has been associated with ductal breast cancer as well as with pulmonary and gastric adenocarcinomas. A correlation between Her2/Neu and p53 has also been reported as overexpression of both proteins has been associated with early invasion and metastasis in bladder cancer.

DESCRIPTION

Antigen: Recombinant human Her2/Neu.
Accession No.: P04626
Host: Mouse
Antibody Subtype: IgG2a
Specificity: Human Her2/Neu. Reactivity with other species has not been investigated.

APPLICATIONS

Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.

STORAGE AND STABILITY

Store at 2-8°C. Do not freeze.

For in vitro investigational use only. Not for use in diagnostic or therapeutic applications.