Catalog No.: 1137
Size: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma-tography.
Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuronal survivial and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors requrie two receptor subunits, the novel glycosylphosphatidylinositol linked protein GFRα and Ret receptor tyrosine kinase GFRβ. Following the identification of GFRα-1 and –2, another receptor in the GFR family was identified in human and mouse and designated GFRα-3. GFRα-3 binds persephin. Thus, persephin, GFRα-3, and Ret PTK form a complex to transmit the persephin signal and to mediate persephin function.
Antigen: Peptide corresponding to aa 347- 360 of mouse GFRα-3.
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes human, mouse, and rat GFRα-3 (approx. 43 kD).
Immunoblotting: use at 1:500-1:1,000 dilution.
Positive control: Tissue lysates of mouse kidney, liver, or heart.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.