Catalog No.: 1133
Size: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma-tography.
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of the kidney and the enteric nervous system. Physiological responses to GDNF require the presence of a novel glycosylphosphatidylinositol linked protein, GDNFRα, a cell surface receptor for GDNF. The cDNAs encoding GDNFRα from human, rat, chicken, and mouse have been cloned. GDNFRα has also been referred to as GFRα-1, Ret ligand 1 (RETL1) and TGF- β-related neurotrophic factor receptor 1 (TmR1). GFRα-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFRα, and the Ret PTK form a complex to transmit the GDNF signal and to mediate GDNF function. GFRα-1 has been identified in brain, liver, kidney, and spleen.
Antigen: Peptide corresponding to aa 369- 382 of human GFRα-1. This peptide sequence is identical to those of mouse and rat.
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes human, mouse, and rat GFRα-1 (approx. 50 kD).
Immunoblotting: use at 1:500 dilution.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.