Product Name Anti-FK-506 Antibody (17301)
Description Anti-FK-506 Mouse Monoclonal Antibody
Species Reactivity Fk-506
Clone ID FK1
Immunogen FK-506 conjugated to bovine serum albumin.
Concentration Lot Specific
Formulation PBS containing 0.1% sodium azide
Buffer Formulation Phosphate Buffered Saline
Buffer Anti-Microbial 0.1% Sodium Azide
Purification Purified by immunoaffinity chromatography
Specificity This antibody recognizes conjugated and non-conjugated FK-506 (Kd=10-9 M).
Target ID FK-506
Research Areas Drugs
Background FK-506 is a novel macrolide with similar, but more potent, immunosuppressant activity than cyclosporine. FK-506 is used for primary or rescue immunosuppression in patients after solid organ transplantation. Clinically relevant side effects of FK-506 administration are nephrotoxicity, neurotoxicity, diabetes mellitus, and hypertension. Most of these side effects are related to blood levels of FK-506 rather than dosage. Therefore, therapeutic drug monitoring of FK-506 is a prerequisite for therapy. The whole blood target level range aimed for in clinical practice is 3.0-20.0 ng/ml and depends on the patient's liver function, the nature of organ transplantation, and the time after transplantation.
Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions This antibody may be used in ELISA and Western blotting to detect FK-506.