FK-506 Monoclonal Antibody
Catalog No.: 17301
Size: 200 ug IgM in PBS, pH 7.4.
FK-506 is a novel macrolide with similar, but more potent, immunosuppressant activity than cyclosporine. FK-506 is used for primary or rescue immunosuppression in patients after solid organ transplantation. Clinically relevant side effects of FK-506 administration are nephrotoxicity, neurotoxicity, diabetes mellitus, and hypertension. Most of these side effects are related to blood levels of FK-506 rather than dosage. Therefore, therapeutic drug monitoring of FK-506 is a prerequisite for therapy. The whole blood target level range aimed for in clinical practice is 3.0-20.0 ng/ml and depends on the patient’s liver function, the nature of organ transplantation, and the time after transplantation.
Antigen: FK-506 conjugated to bovine serum albumin.
Host Species: Mouse
Mouse Isotype: IgM
Preservatives: 0.1% sodium azide.
This antibody recognizes conjugated and non-conjugated FK-506 (Kd=10-9 M).
This antibody may be used in ELISA and Western blotting to detect FK-506.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.