F1A alpha (CT)

Anti-F1Aa Antibody

ORDERING INFORMATION

Catalog No.: 2279
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.

BACKGROUND

Fas and tumor necrosis factor receptor 1 (TNFR1) are two members of the family of death receptors. A novel protein that associates with the intracellular domains of Fas and TNFR1 has been designated image (or FEM1 ). F1A is cleaved by CED-3 and caspase, and it associates with CED-4 and its mammalian homologue Apaf-1. Overexpression of F1A induces apoptosis. F1A is expressed in a variety of human and mouse tissues.

SPECIFICATION SUMMARY

Antigen: Peptide corresponding to aa 609- 622 of human F1A (accession no. AAF05314). This sequence is identical to that of mouse.
Host Species: Rabbit
Stabilizers: None
Preservatives: 0.02% sodium azide

SPECIFICITY

This antibody recognizes human, mouse, and rat F1A (70kDa).

APPLICATIONS

Immunoblotting: use at 1ug/ml.
Immunohistochemistry: use at 5ug/ml.
Positive control: Mouse liver tissue lysate.
These are recommended concentrations. Enduser should determine optimal concentrations for their applications.

DILUTION INSTRUCTIONS

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE AND STABILITY

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.