ENaC alpha Monoclonal Antibody
Catalog No.: 11574
Clone No.: 14E10
MAb Subtype: IgG1
Format: Protein G-purified antibody in PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.
The epithelial sodium channel (ENaC) is a membrane-bound ion-channel that is selectively permeable to Na+ ions and that is assembled as a heterotrimer composed of three homologous subunits α, β, and γ. It is involved primarily in the reabsorption of sodium ions in the collecting ducts of the kidney’s nephrons. These channels mediate the first step of active sodium reabsorption essential for the maintenance of body salt and water homeostasis. In vertebrates, the channels control reabsorption of sodium in kidney, colon, lung and sweat glands; they also play a role in taste perception.
Antigen: Synthetic peptide corresponding to N-terminal aa 46-68 of rat ENaC alpha.
Host Species: Mouse
Gene ID: 25122
Accession No.: NP_113736
Swiss Prot: Q6IRJ1
Specificity: Mouse and rat ENaC alpha
Detection of ~85kDa ENaC alpha with #11574 at 1ug/ml.
Detection of ENaC alpha (green) in paraffin- embedded, formalin-fixed rat kidney with #11574 at 10ug/ml.
These are recommended concentrations. Endusers should determine optimal concentrations for their applications.
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.