Anti-DREAM Antibody (70149)

$362.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	100ug	WB	Human

SKU: 70149 Categories: Antibody Products, Products, Protein Transcription Antibodies

Overview

Product Name Anti-DREAM Antibody (70149)

Description Anti-DREAM Rabbit Polyclonal Antibody

Target DREAM

Species Reactivity Human

Applications WB

Host Rabbit

Clonality Polyclonal

Immunogen Peptide corresponding to aa 26-35 of human DREAM.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by peptide immuno-affinity chromatography

Specificity This antibody recognizes human DREAM (31 kD).

Target Name Calsenilin

Target ID DREAM

Uniprot ID Q9Y2W7

Alternative Names A-type potassium channel modulatory protein 3, DRE-antagonist modulator, DREAM, Kv channel-interacting protein 3, KChIP3

Gene Name KCNIP3

Sequence Location Cytoplasm, Cell membrane, Endoplasmic reticulum, Golgi apparatus, Nucleus

Biological Function Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). {UniProtKB:Q9QXT8}.; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of rPubMed:10676964, PubMed:12829703, PubMed:15485870, PubMed:16123112, PubMed:18957440}.; May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. {PubMed:11259376, PubMed:11988022, PubMed:9771752}.

Research Areas Protein Transcription

Background The human prodynorphin gene, which is involved in memory acquisition and pain, is regulated by its downstream regulatory element (DRE) which acts as a location-dependent gene silencer. DREAM (DRE-antagonist modulator) is a transcriptional repressor. It is the first known Ca+2 binding protein that binds to DNA and regulates transcription.

Handling

Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.

Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.

Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution.

Data Sheet