Anti-DRAK1 (NT) Antibody
Catalog No.: 2147
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis have been identified and designated DRAK1 and DRAK2 for DAP kinase–related apoptosis-inducing protein kinases. DRAKs contain an N-terminal kinase domain and a C- terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases which mediate apoptosis through their catalytic activities. DRAK1 is located in cell nuclei, and the mRNA for DRAK1 is ubiquitously expressed in human tissues.
Antigen: Peptide corresponding to aa 5-19 of human DRAK1 (accession no. Q9UEE5).
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes human DRAK1 (50kDa). No cross-reactivity with DRAK2, DAP or ZIP kinases.
Immunoblotting : use at 1ug/ml.
Immunocytochemistry: use at 2ug/ml.
Positive control: Whole cell lysate from A431 or MOLT4 cells.
These are recommended concentrations. Enduser should determine optimal concentrations for their applications.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.