Anti-DR4 (CT) Antibody
Catalog No.: 2404
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain-containing receptors, TNFR1 and Fas. Another cell death receptor was recently identified and designated DR4. The ligand for DR4 has been designated TRAIL and is a new member of the TNF family. Therefore, DR4 is also called TRAIL receptor-1. DR4 is expressed in most human tissues including spleen, peripheral blood, small intestine, and thymus. Like TNFR1, Fas and DR3, DR4 mediates TRAIL-induced apoptosis and NF- B activation in many tissues and cells.
Antigen: Peptide corresponding to aa 427-445 at the C-terminus of human DR4 (accession no. ACC51226).
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes full-length human DR4 (57kDa).
Immunoblotting : use at 1ug/ml.
Immunocytochemistry: use at 10ug/ml.
Positive control: Whole cell lysate from HeLa cells.
These are recommended concentrations. Enduser should determine optimal concentrations for their applications.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.