Anti-DcR3 (NT) Antibody
Catalog No.: 2140
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
Several novel members in the TNF receptor family, including DR3, DR4, DR5 and DR6, function as cell death receptors. Two decoy receptors, DcR1 and DcR2, compete with DR4 and DR5 for binding of their ligand, TRAIL. Another decoy receptor, DcR3/TR6 was discovered recently. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane- associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL- and LIGHT-induced apoptosis. DcR3 transcript is expressed in some lung and colon carcinomas and in some normal tissues.
Antigen: Peptide corresponding to aa 31-46 of human DcR3 precursor (accession no. AF104419).
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes human, mouse, and rat DcR3 (33kDa).
Immunoblotting: use at 1ug/ml.
These are recommended concentrations. Enduser should determine optimal concentrations for their applications.
Positive control: Human heart tissue lysate.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.