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Anti-DC-UbP Antibody (11094)

Host Quantity Applications Species Reactivity Data Sheet  
Rabbit 100ug WB,ELISA Human
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SKU: 11094 Categories: , ,
Overview
Product Name Anti-DC-UbP Antibody (11094)
Description Anti-DC-UbP Rabbit Polyclonal Antibody
Target DC-UbP
Species Reactivity Human
Applications WB,ELISA
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to amino acids 197-212 (SGRPLTDKMKFEELKI) of human DC-UbP precursor conjugated to KLH at the N-terminus. This sequence is 93
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by peptide immuno-affinity chromatography
Specificity Information
Specificity This antibody recognizes human, mouse, and rat DC-UbP.
Target Name Ubiquitin domain-containing protein 2
Target ID DC-UbP
Uniprot ID Q8WUN7
Alternative Names Dendritic cell-derived ubiquitin-like protein, DC-UbP, Ubiquitin-like protein SB72
Gene Name UBTD2
Gene ID 92181
Accession Number NP_689490.2
Sequence Location Cytoplasm
Research Areas Apoptosis
Background DC-UbP is a 26 kDa ubiquitin-like protein from dendritic cells comprised of 106 amino acids. The ubiquitin domain in DC-UbP shares 28.6% identity with ubiquitin, but it does not have the conserved C-terminus Gly-Gly of ubiquitin required for ubiquitinization. DC-UbP is found in cytoplasm (particularly in mitochondria), and DC- UbP mRNA is expressed in various tumor cell types, but not in normal adult human tissues, which suggests a role for DC-UbP in tumorigenesis. In addition, DC-UbP appears to be downregulated during cellular differentiation and apoptosis.
Application Images
Additional Information
Handling
Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
Dilution Instructions Dilute in PBS or medium which is identical to that used in the assay system.
Application Instructions ELISA: 1:1,000-1:10,000 with Dc-UbP on the solid phase.

The investigator should determine the optimal dilution for their application.
References & Data Sheet
References Liu S, et al. 2003 Biochem Biophys Res Commun 300: 800-805.