Anti-Cytokeratin 19 Antibody (34059)

Host Quantity Applications Species Reactivity Data Sheet  
Mouse 100ul IHC Human
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Overview
Product Name Anti-Cytokeratin 19 Antibody (34059)
Description Anti-Cytokeratin 19 Mouse Monoclonal Antibody
Target Cytokeratin 19
Species Reactivity Human
Applications IHC
Host Mouse
Clonality Monoclonal
Clone ID G019.1
Isotype IgG2a
Immunogen Recombinant human Cytokeratin 19.
Properties
Form Liquid
Concentration Lot Specific
Formulation Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.
Buffer Formulation Tris
Buffer pH pH 7.3-7.7
Buffer Anti-Microbial 0.1% Sodium Azide
Buffer Protein Stabilizer 1% Bovine Serum Albumin
Format Purified
Purification Purified by immunoaffinity chromatography
Specificity Information
Specificity Human Cytokeratin 19. Reactivity with other species has not been investigated.
Target Name Keratin, type I cytoskeletal 19
Target ID Cytokeratin 19
Uniprot ID P08727
Alternative Names Cytokeratin-19, CK-19, Keratin-19, K19
Gene Name KRT19
Biological Function Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {PubMed:16000376}.
Research Areas Cancer research
Background Cytokeratin19 is the smallest member (40kDa) of the keratin family. It forms intermediate filaments in the intracytoplasmic cytoskeleton of epithelial tissue and provides mechanical support. Cytokeratin 19 is identified in epithelial malignancies such as carcinomas of colon, stomach, pancreas, biliary tract, liver, breast, and thyroid papillary carcinomas.
Application Images
Description Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Detection of Cytokeratin 19 in human colon with #34059 diluted 1:100-1:200.
Additional Information
Handling
Storage Store at 2-8°C. Do not freeze.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions

Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.
References & Data Sheet