Anti-CD2 Antibody (34053)

$289.00

Host Quantity Applications Species Reactivity Data Sheet  
Mouse 100ul IHC Human
SKU: 34053 Categories: , , Tag:
Overview
Product Name Anti-CD2 Antibody (34053)
Description Anti-CD2 Mouse Monoclonal Antibody
Target CD2
Species Reactivity Human
Applications IHC
Host Mouse
Clonality Monoclonal
Clone ID G531.1
Isotype IgG1
Immunogen Recombinant human CD2.
Properties
Form Liquid
Concentration Lot Specific
Formulation Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.
Buffer Formulation Tris
Buffer pH pH 7.3-7.7
Buffer Anti-Microbial 0.1% Sodium Azide
Buffer Protein Stabilizer 1% Bovine Serum Albumin
Format Purified
Purification Purified by immunoaffinity chromatography
Specificity Information
Specificity Human CD2. Reactivity with other species has not been investigated.
Target Name T-cell surface antigen CD2
Target ID CD2
Uniprot ID P06729
Alternative Names Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5, CD antigen CD2
Gene Name CD2
Sequence Location Cell membrane, Single-pass type I membrane protein
Biological Function CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
Research Areas Cancer research
Background CD2 (cluster of differentiation 2) is a cell adhesion molecule found on the surface of T cells and natural killer (NK) cells. The majority of T cell lymphomas and leukemias also express CD2 which makes it possible to distinguish those conditions from B cell neoplasms.
Application Images
Description Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes. Detection of CD2 in human tonsil with #34053 diluted 1:100-1:200.
Additional Information
Handling
Storage Store at 2-8°C. Do not freeze.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions

Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.
References & Data Sheet