Anti-Cav1.3 Ca+2 Channel Monoclonal Antibody
Catalog No.: 11504 (clone S38-8)
Size: 100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Cav1.3, also known as calcium channel, voltage-dependent, L-type, alpha 1D subunit (CACNA1D), is a human gene. Cav1.3 subunits are primarily expressed in neurons and neuroendocrine cells. Some studies suggest that Cav1.3 is also found in the atria and may play a significant role in atrial arrhythmias. In addition, Cav 1.3 carries the primary sensory receptors of the mammalian cochlea and is also expressed in the electromotile outer ear hair cells.
Antigen: Fusion protein aa 2025-2161 (C-terminus) of rat Cav1.3 (accession number P27732).
Host Species: Mouse
Antibody Class: IgG1
This antibody recognizes human, mouse, and rat Cav1.3. It does not cross-react with Cav1.2.
Immunoblotting: use at 1-10ug/ml. A band of ~250kDa is detected.
Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml
Immunofluorescence: use at 1-10ug/ml
These are recommended concentrations. User should determine optimal concentrations for their application.
Positive control: Rat brain lysate
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid repeated freezing and thawing.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.