Anti-Cav1.2 Ca+2 Channel Monoclonal Antibody
Catalog No.: 11502 (clone S57-46)
Size: 100ug in PBS, pH 7.4; 50% glycerol, 0.09% sodium azide. Purified by Protein G affinity chromatography.
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. Cav1.2 is a cardiac L-type calcium channel, and it is important for excitation and contraction of heart muscle. It may be associated with a variant of Long QT syndrome called Timothy’s syndrome and also with Brugada syndrome. Some investigations also suggest it is related to bipolar disease.
Antigen: Fusion protein aa 1507-1733 (intracellular carboxyl terminus) of rabbit Cav1.2 (accession number P15381).
Host Species: Mouse
Antibody Class: IgG2b
This antibody recognizes human, mouse, and rat Cav1.2
Immunoblotting: use at 1-10ug/ml. A band of ~2400kDa is detected.
Immunohistochemistry and Immunocytochemistry: use at 0.1-1ug/ml
Immunofluorescence: use at 1-10ug/ml
These are recommended concentrations. User should determine optimal concentrations for their application.
Positive control: Rat brain lysate
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid repeated freezing and thawing.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.