Catalog No.: 11026
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
Caspases are a family of cysteine proteases. Caspase-8 is an initiator caspase that was identified as a member of the Fas/APO-1 death-inducing signaling complex. The adaptor molecule FADD couples procaspase-8 to the Fas receptor death domain; subsequent oligomerization promotes procaspase-8 autoactivation. FLIP, a catalytically inactive caspase-8-like molecule inhibits these interactions and thus can inhibit apoptosis.
Antigen: Synthetic peptide corresponding to 16 amino acids at the C-terminus of human Caspase-8 isoform A (accession no. NP_001219).
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes human, mouse, and rat Caspase-8 (18kDa).
Immunoblotting: use at 0.5-2ug/ml.
Positive control: Jurkat cell lysate.
Immunocytochemistry: use at 2ug/ml.
These are recommended concentrations. Enduser should determine optimal concentrations for their applications.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.