Calmodulin-Dependent Protein Kinase II (CaMKII) Polyclonal Antibody
Catalog nos.: 56370-50, (50ug) 56370-200 (200ug)
Format: Protein A-purified antibody in PBS, 50% glycerol, 0.09% sodium azide.
Calmodulin-dependent protein kinase II (CaMKII) is a serine/threonine-specific protein kinase that is regulated by the Ca2+/calmodulin complex. CaMKII is involved in many signaling cascades and is thought to be an important mediator of learning and memory. CaMKII is also necessary for Ca2+ homeostasis and reuptake in cardiomyocytes, chloride transport in epithelia, positive T-cell selection, and CD8 T-cell activation. CaMKII has 28 different isoforms that derive from the alpha, beta, gamma, and delta genes. Misregulation of CaMKII is linked to Alzheimer’s disease, Angelman syndrome, and heart arrhythmia.
Antigen: Synthetic peptide corresponding to aa 7-20 (N-terminus) of rat CaMKII delta isoform conjugated to KLH.
Accession no.: P15791
Gene ID: 25246
Host Species: Rabbit
Antibody Class: Polyclonal
Specificity: This antibody recognizes alpha, delta, and gamma isoforms of human, mouse, rat, bovine, hamster, guinea pig, chicken, and rabbit CaMKII.
Immunoblotting: Use at 1-5ug/ml. A band of ~50-60 kDa is detected.
Immunohistochemistry: use at 1-10ug/ml.
These are recommended concentrations. Endusers should determine optimal concentrations for their applications.
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Store in appropriate aliquots to avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not intended for therapeutic or diagnostic procedures.