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Anti-Brain-Derived Neurotrophic Factor (BDNF) Antibody (50170-500)

$453.00

Host Quantity Applications Species Reactivity Data Sheet  
Mouse 500ug ELISA Human
SKU: 50170-500 Categories: , ,
Overview
Product Name Anti-Brain-Derived Neurotrophic Factor (BDNF) Antibody (50170-500)
Description Anti-Human Brain Derived Neurotrophic Factor Mouse Monoclonal Antibody
Target Brain-Derived Neurotrophic Factor (BDNF)
Species Reactivity Human
Applications ELISA
Host Mouse
Clonality Monoclonal
Clone ID ANT-128
Isotype IgG
Immunogen Recombinant human BDNF
Properties
Form Lyophilized
Formulation Lyophilized at 1mg/ml in PBS.
Buffer Formulation Phosphate Buffered Saline
Format Purified
Purification Purified by affinity chromatography
Specificity Information
Target Name Brain-derived neurotrophic factor
Target ID Brain-Derived Neurotrophic Factor (BDNF)
Uniprot ID P23560
Gene Name BDNF
Gene ID 113505
Sequence Location Secreted
Biological Function Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. {PubMed:11152678, PubMed:12553913, PubMed:29909994}.; [BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity). {UniProtKB:P21237, PubMed:24908487, PubMed:29909994}.
Research Areas Growth Factors, Cytokines, Receptors
Application Images
Additional Information
Handling
Storage Lyophilized product is stable at 4°C in a dry environment. After reconstitution, store at -20°C. Avoid multiple freeze-thaw cycles.
Dilution Instructions Reconstitute with sterile H2O. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Application Instructions ELISA: use at 0.1-1ug/ml with BDNF on the solid phase.

These are recommended concentrations.

End users should determine optimal concentrations for their applications.
References & Data Sheet