Anti-β-Defensin-3 Antibody

$374.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	100ug	WB	Human

SKU: 18713 Categories: Antibody Products, Infectious Disease Antibodies, Products

Overview

Product Name Anti-β-Defensin-3 Antibody (18713)

Description Anti-β-Defensin-3 Rabbit Polyclonal Antibody

Target β-Defensin-3

Species Reactivity Human

Applications WB

Host Rabbit

Clonality Polyclonal

Immunogen Full-length human beta- defensin 3.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by Protein A affinity chromatography

Specificity This antibody specifically recognizes human beta-defensin-3, a nonhemolytic antimicrobial peptide originally isolated from human lesional psoriatic scales and cloned from human keratinocytes. Beta-defensin-3 appears to play a role in natural epithelial defense against infections by a broad spectrum of pathogenic microorganisms.

Target Name β-defensin 103

Target ID β-Defensin-3

Uniprot ID P81534

Alternative Names β-defensin 3, BD-3, DEFB-3, HBD3, hBD-3, Defensin, β 103, Defensin-like protein

Gene Name DEFB103A

Accession Number NP_001075020.1

Sequence Location Secreted.

Biological Function Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. {PubMed:11085990}.

Research Areas Infectious Disease

Handling

Storage Store at 2 - 8ºC. Do not Freeze.

Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.

Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution. In immunoblots, a band of approximately 5 kD is detected.

Data Sheet