Anti-β-Defensin-3 Antibody (18713)

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	100ug	WB	Human

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SKU: 18713 Categories: Antibody Products, Infectious Disease Antibodies, Products

Overview

Product Name Anti-β-Defensin-3 Antibody (18713)

Description Anti-β-Defensin-3 Rabbit Polyclonal Antibody

Target β-Defensin-3

Species Reactivity Human

Applications WB

Host Rabbit

Clonality Polyclonal

Immunogen Full-length human beta- defensin 3.

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by immunoaffinity chromatography

Specificity This antibody specifically recognizes human beta-defensin-3, a nonhemolytic antimicrobial peptide originally isolated from human lesional psoriatic scales and cloned from human keratinocytes. Beta-defensin-3 appears to play a role in natural epithelial defense against infections by a broad spectrum of pathogenic microorganisms.

Target Name β-defensin 103

Target ID β-Defensin-3

Uniprot ID P81534

Alternative Names β-defensin 3, BD-3, DEFB-3, HBD3, hBD-3, Defensin, β 103, Defensin-like protein

Gene Name DEFB103A

Accession Number NP_001075020.1

Sequence Location Secreted.

Biological Function Exhibits antimicrobial activity against Gram-positive bacteria S.aureus and S.pyogenes, Gram-negative bacteria P.aeruginosa and E.coli and the yeast C.albicans. Kills multiresistant S.aureus and vancomycin-resistant E.faecium. No significant hemolytic activity was observed. {PubMed:11085990}.

Research Areas Infectious Disease

Handling

Storage This antibody is stable for at least one (1) year at -20°C to -70°C. Store antibody in appropriate aliquots to avoid multiple freeze-thaw cycles.

Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.

Application Instructions Immunoblotting: use at 1:500-1:1,000 dilution. In immunoblots, a band of approximately 5 kD is detected.

Data Sheet