Anti-Bcl10 (NT) Antibody
Catalog No.: 2161
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
A novel CARD containing protein was recently identified and designated Bcl10, CIPER, mE10, CARMEN, and CLAP. Bcl10 is a cellular homolog of the equine herpesvirus-2 E-10 gene. Overexpression of Bcl10 induces JNK, p38, and NF- B activation. Bcl10 interacts with caspase- 9, enhances pro-caspase-9 processing, and induces apoptosis through caspase-9 activation. Bcl10 exhibits a variety of mutations in MALT lymphoma and in B and T cell lymphomas indicating that it may be commonly involved in the pathogenesis of human tumors. Bcl10 is expressed in many human and murine tissues and cell lines.
Antigen: Peptide corresponding to aa 5-19 of human Bcl10.
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes human Bcl10 (31kDa).
Immunoblotting: use at 1ug/ml.
Immunocytochemistry: use at 1ug/ml.
These are recommended concentrations. Enduser should determine optimal concentration for their application.
Positive control: Whole cell lysate of Raji cells.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.