Anti-BCAS1 / NABC1 Antibody

$413.00

Host Quantity Applications Species Reactivity Data Sheet  
Rabbit 100ug WB,IHC Human
SKU: 34017 Categories: , ,
Overview
Product Name Anti-BCAS1 / NABC1 Antibody (34017)
Description Anti-BCAS1/NABC1 Rabbit Polyclonal Antibody
Target BCAS1 / NABC1
Species Reactivity Human
Applications WB,IHC
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to amino acids 532-550 of human BCAS1/NABC1.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by Protein A affinity chromatography
Specificity Information
Specificity This antibody recognizes human BCAS1/NABC1.
Target Name Breast carcinoma-amplified sequence 1
Target ID BCAS1 / NABC1
Uniprot ID O75363
Alternative Names Amplified and overexpressed in breast cancer, Novel amplified in breast cancer 1
Gene Name BCAS1
Sequence Location Cytoplasm
Biological Function Required for myelination. {UniProtKB:Q80YN3}.
Research Areas Cancer research
Background Breast Carcinoma Amplified Sequence 1 (BCAS1), also known as Novel Amplified in Breast Cancer 1 (NABC1) was isolated from a region at 20q13 and is amplified in several tumor types. It is associated with more aggressive tumor phenotypes. BCAS1/NABC1 is highly expressed in some, but not all, breast cancer cell lines and in some breast tumors at 20q13.2. The BCAS1/NABC1 gene is predicted to encode a protein of 584 amino acids with no significant homology to other proteins.
Application Images
Description Immunoblotting : use at 1-5ug/ml. A band of approximately 60 kDa is detected, however, protein dimerization may occur.
Additional Information
Handling
Storage Store at 2 - 8ºC. Do not Freeze.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions Immunoblotting : use at 1-5ug/mL.A band of approximately 60kDa is detected, however, protein dimerization may occur.

These are recommended concentrations. User should determine optimal concentrations for their applications.
References & Data Sheet
References Chang, N.S et al. Oncogene (2005) 24: 714-723.; Aqeilan, R.I. et al. Cancer Res (2004) 64: 8256-8261.; Sze, C.I. et al. J Biol Chem (2004) 279: 30498-30506.