Anti-BAFF-R/BR3 (CT) Antibody (40204)

Host Quantity Applications Species Reactivity Data Sheet  
Rabbit 100ug ELISA,WB,IHC-P,IF Human, Mouse, Rat
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Overview
Product Name Anti-BAFF-R/BR3 (CT) Antibody (40204)
Description Anti-BAFF-R (CT) BR3 Rabbit Polyclonal Antibody
Target BAFF-R/BR3 (CT)
Species Reactivity Human, Mouse, Rat
Applications ELISA,WB,IHC-P,IF
Host Rabbit
Clonality Polyclonal
Isotype IgG
Immunogen Peptide corresponding to aa 169-183 at the C-terminus of human BAFF-R.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by peptide immuno-affinity chromatography
Specificity Information
Specificity This antibody recognizes human, mouse, and rat BAFF-R.
Target Name BAFF receptor
Target ID BAFF-R/BR3 (CT)
Uniprot ID Q5H8V1
Gene Name TNFRSF13C
Research Areas Growth Factors, Cytokines, Receptors
Background Members of the TNF superfamily are involved in regulation of immune responses and induction of apoptosis. A novel member of the TNF superfamily, BAFF/BlyS has been characterized as a B cell activator since it stimulates B cell proliferation and immunoglobulin secretion. Two receptors for BAFF (TACI and BCMA) were first identified. A third receptor was recently identified and designated BAFF-R and BR3 for BlyS receptor 3. BAFF-R is specific for BAFF and plays a major role in BAFF-induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases and activate NF-kappaB and c-jun N-terminal kinase.
Application Images
Description Western blot analysis of BAFF Receptor in human (H), mouse (M), and rat (R) spleen tissue lysates with BAFF Receptor antibody at 5 ug/mL.
Description Immunohistochemistry of BAFF-R in human spleen tissue with BAFF-R antibody at 5 ug/mL.
Description Immunofluorescence of BAFF-R in human spleen tissue with BAFF-R antibody at 20 ug/ml. Red: BAFF Receptor Antibody (40204)
Blue: DAPI staining
Description Immunohistochemistry of BAFF Receptor in human tonsil tissue with BAFF Receptor antibody at 5 ug/mL.
Additional Information
Handling
Storage This antibody is stable for one (1) year at 4°C or -20°C. Avoid multiple freeze- thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions Immunoblotting: use at 2-5 ug/mL.

Positive control: human, mouse, or rat spleen tissue lysates.

Immunohistochemistry: use at 5 ug/mL.

Positive control: human tonsil.
References & Data Sheet