Anti-BAFF-R / BR3 (CT) Antibody
Catalog No.: 40204
Size: 100 ug IgG in 100 ul PBS, pH 7.4, purified by immunoaffinity chroma- tography.
Members of the TNF superfamily are involved in regulation of immune responses and induction of apoptosis. A novel member of the TNF superfamily, BAFF/BlyS has been characterized as a B cell activator since it stimulates B cell proliferation and immunoglobulin secretion. Two receptors for BAFF (TACI and BCMA) were first identified. A third receptor was recently identified and designated BAFF-R and BR3 for BlyS receptor 3. BAFF-R is specific for BAFF and plays a major role in BAFF-induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases and activate NF-κB and c-jun N-terminal kinase.
Antigen: Peptide corresponding to aa 169-183 at the C-terminus of human BAFF-R.
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes human, mouse, and rat BAFF-R.
Immunoblotting: use at 2-5 ug/ml. Positive control: human, mouse, or rat spleen tissue lysates.
Immunohistochemistry: use at 5 ug/ml. Positive control: human tonsil.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for one (1) year at 4°C or -20°C. Avoid multiple freeze- thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.