Anti-BACE2 (NT) Antibody
Catalog No.: 2247
Size: 100 ug IgG in 200 ul PBS, pH 7.4, purified by immunoaffinity chroma-tography.
Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Aβ peptide is generated as a result of proteolytic cleavage of the β-amyloid protein precursor (APP) at β- and γ-sites. β-secretase was recently identified and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently identified and designated BACE2, or Asp1, DRAP (for Down region aspartic protease), or memapsin 1. BACE2 cleaves APP at the β- site and at a different site within Aβ. BACE2 is found on chromosome 21q22 3, the ‘Down critical region’, suggesting that BACE2 and Aβ may also contribute to the pathogenesis of Down syndrome.
Antigen: Peptide corresponding to aa 44-59 of human BACE2.
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes human, mouse, and rat BACE2 (approx. 75 kD).
Immunoblotting: use at 1:500-1:1,000 dilution.
Positive control: Human heart tissue lysate.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.