BACE2 (NT)

Anti-BACE2 (NT) Antibody

ORDERING INFORMATION

Catalog No.: 2247
Size: 100 ug IgG in 200 ul PBS, pH 7.4, purified by immunoaffinity chroma-tography.

BACKGROUND

Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Aβ peptide is generated as a result of proteolytic cleavage of the β-amyloid protein precursor (APP) at β- and γ-sites. β-secretase was recently identified and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). A BACE homolog was recently identified and designated BACE2, or Asp1, DRAP (for Down region aspartic protease), or memapsin 1. BACE2 cleaves APP at the β- site and at a different site within Aβ. BACE2 is found on chromosome 21q22 3, the ‘Down critical region’, suggesting that BACE2 and Aβ may also contribute to the pathogenesis of Down syndrome.

SPECIFICATION SUMMARY

Antigen: Peptide corresponding to aa 44-59 of human BACE2.
Host Species: Rabbit
Stabilizers: None
Preservatives: 0.02% sodium azide.

SPECIFICITY

This antibody recognizes human, mouse, and rat BACE2 (approx. 75 kD).

APPLICATIONS

Immunoblotting: use at 1:500-1:1,000 dilution.
Positive control: Human heart tissue lysate.

DILUTION INSTRUCTIONS

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE AND STABILITY

This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.

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