Anti-B-Cell Maturation protein (BCMA) Antibody

$455.00

Host Quantity Applications Species Reactivity Data Sheet  
Rabbit 100ug ELISA,WB,IHC-P,IF Human
SKU: 40206 Categories: , ,
Overview
Product Name Anti-B-Cell Maturation protein (BCMA) Antibody (40206)
Description Anti-BCMA Rabbit Polyclonal Antibody
Target B-Cell Maturation protein (BCMA)
Species Reactivity Human
Applications ELISA,WB,IHC-P,IF
Host Rabbit
Clonality Polyclonal
Isotype IgG
Immunogen A synthetic peptide corresponding to the carboxy terminus of human BCMA.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by Protein A affinity chromatography
Specificity Information
Specificity This antibody recognizes human BCMA (B Cell Maturation Protein). BCMA is a receptor for BAFF and April, two novel members of the TNF superfamily of proteins regulating immune response and the induction of apoptosis through the activation of NF-kappaB and c-jun N- terminal kinase.
Target Name Tumor necrosis factor receptor superfamily member 17
Target ID B-Cell Maturation protein (BCMA)
Uniprot ID Q02223
Alternative Names B-cell maturation protein, CD antigen CD269
Gene Name TNFRSF17
Sequence Location Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Note=Perinuclear Golgi-like structures.
Biological Function Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {PubMed:10801128, PubMed:10903733, PubMed:10973284}.
Research Areas Growth Factors, Cytokines, Receptors
Application Images
Description Western blot analysis of BCMA in (A) human spleen tissue lysate, (B) K562, and (C) U937 cell lysates with BCMA antibody at 5 ug/mL.
Description Immunohistochemistry of BCMA in human spleen tissue with BCMA antibody at 5 ug/mL.
Description Immunofluorescence of BCMA in Human Spleen tissue with BCMA antibody at 10 ug/mL.
Description Immunohistochemistry of BCMA in human spleen tissue with BCMA antibody at 10 ug/mL.
Additional Information
Handling
Storage Store at 2 - 8ºC. Do not Freeze.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions Western Blot: Use at 2-5 ug/ml. A band of approximately 27 kD is detected using K562 cell lysate as a Positive control.
References & Data Sheet