Anti-ARC (CT) Antibody
Catalog No.: 2413
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
A novel CARD domain-containing protein was recently identified and designated ARC (apoptosis repressor with CARD). ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1, and DR3. The messenger RNA of ARC is primarily expressed in skeletal muscle and cardiac tissue.
Antigen: Peptide corresponding to aa 191- 208 of human ARC.
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes full-length ARC (25 kD).
Immunoblotting: use at 1-10ug/ml.
Immunohistochemistry: use at 5ug/ml.
Immunohistochemistry of ARC in human heart tissue
Positive control: Whole cell lysate of HeLa, KB, and A549 cells.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.