Anti-APP (CT) Antibody
Catalog No.: 2136
Size: 100 ug IgG in PBS, pH 7.4, purified by immunoaffinity chroma-tography.
Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. The β-amyloid protein precursor (APP) is cleaved by β-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for γ-secretase to generate the 4 kD amyloid-β peptide which is deposited in the brain.
Antigen: Peptide corresponding to aa 737- 751 of human amyloid protein precursor (APP) or aa 85-99 of the C99 fragment generated by β- secretase cleavage. The sequences are identical to those of monkey, mouse, rat, chicken, and a variety of other species.
Host Species: Rabbit
Preservatives: 0.02% sodium azide.
This antibody recognizes human, mouse, and rat APP and the C99 fragment.
Immunoblotting: use at 1:500-1:1,000 dilution.
Positive control: Mouse brain lysate.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.