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Anti-Angiotensin Converting Enzyme Antibody (19501)

Host Quantity Applications Species Reactivity Data Sheet  
Mouse 100ug ELISA,IHC,FACS Human, Mouse, Bovine
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SKU: 19501 Categories: , ,
Overview
Product Name Anti-Angiotensin Converting Enzyme Antibody (19501)
Description Anti-Angiotensin Converting Enzyme Human Mouse Monoclonal Antibody
Target Angiotensin Converting Enzyme
Species Reactivity Human, Mouse, Bovine
Applications ELISA,IHC,FACS
Host Mouse
Clonality Monoclonal
Clone ID 3.1.1
Isotype IgM
Immunogen ACE purified from rat lung.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification PEG Purified
Specificity Information
Specificity This antibody reacts specifically with human, bovine, and murine ACE and with ACE-positive endothelial cells.

DILUTION INSTRUCTIONS

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE AND STABILITY

These antibodies are stable for at least one (1) year at -20oC to -70oC. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

REFERENCE

Auerbach, R. et al. (1982) Proc NatlAcad Sci USA 79: 7891.For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures

Target Name Angiotensin-converting enzyme
Target ID Angiotensin Converting Enzyme
Uniprot ID P12821
Alternative Names ACE, EC 3.2.1.-, EC 3.4.15.1, Dipeptidyl carboxypeptidase I, Kininase II, CD antigen CD143 [Cleaved into: Angiotensin-converting enzyme, soluble form]
Gene Name ACE
Sequence Location [Angiotensin-converting enzyme, soluble form]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm
Biological Function Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety.
Research Areas Enzymes
Application Images
Additional Information
Handling
Storage These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions This antibody may be used in ELISA,

Immunohistochemistry, and flow cytometry for detection of ACE or ACE-positive cells. Other applications are under investigation.
References & Data Sheet