Amyloid Oligomer αβ

Amyloid Oligomer αβ Polyclonal Antibody

ORDERING INFORMATION

Catalog No.: 57006 (A11)
Size: 100ul purified rabbit immunoglobulin (0.5mg/ml) in phosphate-buffered saline, pH 7.0, 0.09% sodium azide and 50% glycerol.

BACKGROUND

Amyloid monomeric proteins can oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non- disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibers. These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer’s symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson’s disease, and accumulation of polyglutamine-containing aggregates in Huntington’s disease.

SPECIFICATION SUMMARY

Antigen: Synthetic molecular mimic of soluble oligomers.
Host Species: Rabbit
Antibody Class: Polyclonal

SPECIFICITY

This antibody recognizes a peptide backbone epitope that is common to all types of amyloid oligomers but is not found in native proteins, amyloidogenic monomers, or mature amyloid fibrils.

APPLICATIONS

Immunoblotting: use at 0.5-1ug/ml
Dot blot: use at 0.5-1ug/ml
ELISA: use at 1-10ug/ml with amyloid oligomer-containing samples on the solid phase.
These are recommended concentrations. Enduser should determine optimal concentrations for their applications.

DILUTION INSTRUCTIONS

Dilute in PBS or medium which is identical to that used in the assay system.

STORAGE AND STABILITY

This product is stable for at least 1 year at -20°C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.

For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.

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