Amyloid Fibrils (OC) Polyclonal Antibody
Catalog No.: 57005
Size: 100ul purified rabbit immunoglobulin in phosphate-buffered saline, pH 7.0, 0.09% sodium azide and 50% glycerol.
Amyloid monomeric proteins can oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non- disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibers. These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer’s symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson’s disease, and accumulation of polyglutamine-containing aggregates in Huntington’s disease.
Antigen: Fibrils prepared from human Aβ42 peptide.
Host Species: Rabbit
Antibody Class: Polyclonal
This antibody recognizes epitopes common to many human amyloid fibrils and fibrillar oligomers but not prefibrillar oligomers or natively folded proteins. Predicted to recognize mouse and rat based on sequence homology.
Immunoblotting: use at 1:1,000 dilution.
Dot blot: use at 1:1,000 dilution.
Immunohistochemistry: use at 1:1,000 dilution.
ELISA: use at 1:1,000 dilution with amyloid fibril-containing samples on the solid phase.
These are recommended concentrations. Enduser should determine optimal concentrations for their applications.
Dilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITY
This product is stable for at least 1 year at -20°C. Freeze in multiple aliquots to avoid repeated freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures.