Alpha-1-Antitrypsin Monoclonal Antibodies
ORDERING INFORMATION
Catalog No. 13701 |
Clone No. 1AT10-105.10 |
MAb Subtype IgG2a |
Size 100ug, 500ug |
Library Pack No. 137101 |
100ug/clone All 4 clones |
13702 |
1AT11-210.1 |
IgG1 |
100ug, 500ug |
||
13703 |
1AT11-209.3 |
IgG1 |
100ug, 500ug |
||
13704 |
1AT11-213.5 |
IgG1 |
100ug, 500ug |
Format: Protein G-purified antibody in PBS, pH 7.4.
BACKGROUND
Alpha-1 Antitrypsin (α1AT) is a protease inhibitor of the serpin superfamily. It is generally known as serum trypsin inhibitor and is also referred to as alpha-1 proteinase inhibitor (α1PI) because it inhibits multiple proteases. It protects tissues from proteases of inflammatory cells, particularly neutrophil elastase, and has a reference range in blood of 1.5 – 3.5 gram/liter, but the concentration can rise significantly in cases of acute inflammation. In its absence (such as in α1AT deficiency), neutrophil elastase is free to break down elastin, which contributes to the elasticity of the lungs, resulting in respiratory complications such as emphysema, or COPD (chronic obstructive pulmonary disease) in adults and cirrhosis in adults or children.
SPECIFICATION SUMMARY
Antigen: Purified human serum alpha-1-antitrypsin.
Host Species: Mouse
Specificity: These antibodies specifically recognize human serum alpha-1-antitrypsin. They do not cross-react with alpha-1-antichymotrypsin.
APPLICATIONS
These antibodies have been qualified for use in ELISA to detect human α1AT. Endusers should determine optimal concentrations for their applications.
DILUTION INSTRUCTIONS
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not intended for use in therapeutic or diagnostic procedures.