Alpha-1-Antichymotrypsin Monoclonal Antibodies
ORDERING INFORMATION
Catalog No. 13801 |
Clone No. 1AC10-109.5 |
MAb Subtype IgG2a |
Size 100ug, 500ug |
Library Pack No. 138101 |
100ug/clone All 4 clones |
13802 |
1AC10-118.2 |
IgG1 |
100ug, 500ug |
||
13803 |
1AC10-128.1 |
IgG1 |
100ug, 500ug |
||
13804 |
1AC10-143.1 |
IgG2a |
100ug, 500ug |
Format: Protein G-purified antibody in PBS, pH 7.4.
BACKGROUND
Alpha 1-antichymotrypsin (α1AC) is an alpha globulin glycoprotein produced in the liver that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. α1AC inhibits the activity of proteases such as cathepsin G from neutrophils and chymases from mast cells by cleaving them into different conformations. This activity protects tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. α1AC is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease, and mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. It is also associated with the pathogenesis of Alzheimer’s disease as it enhances the formation of amyloid-fibrils.
SPECIFICATION SUMMARY
Antigen: Purified human serum alpha-1-antichymotrypsin.
Host Species: Mouse
Specificity: These antibodies specifically recognize human serum alpha-1-antichymotrypsin. They do not cross-react with alpha-1-antitrypsin.
APPLICATIONS
These antibodies have been qualified for use in ELISA to detect human α1AC. Endusers should determine optimal concentrations for their applications.
DILUTION INSTRUCTIONS
Dilute in PBS or medium that is identical to that used in the assay system.
STORAGE AND STABILITY
These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not intended for use in therapeutic or diagnostic procedures.