Anti-Akirin 1 Antibody

$455.00

Host	Quantity	Applications	Species Reactivity	Data Sheet
Rabbit	100ug	ELISA,WB	Human, Mouse, Rat

SKU: 56264 Categories: Antibody Products, Neuroscience and Signal Transduction Antibodies, Products

Overview

Product Name Anti-Akirin 1 Antibody (56264)

Description Anti-Akirin1 Rabbit Polyclonal Antibody

Target Akirin 1

Species Reactivity Human, Mouse, Rat

Applications ELISA,WB

Host Rabbit

Clonality Polyclonal

Isotype IgG

Immunogen N-terminal domain peptide sequence (16 amino acids) derived from human Akirin1 (GenBank accession no. CAI16710).

Properties

Form Liquid

Concentration Lot Specific

Formulation PBS, pH 7.4.

Buffer Formulation Phosphate Buffered Saline

Buffer pH pH 7.4

Format Purified

Purification Purified by Protein A affinity chromatography

Specificity This antibody recognizes human, mouse, and rat Akirin1.

Target Name Akirin-1

Target ID Akirin 1

Uniprot ID Q9H9L7

Gene Name AKIRIN1

Sequence Location Nucleus

Biological Function Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis. May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway. {UniProtKB:Q99LF1}.

Research Areas Neuroscience

Background Akirin is a recently discovered nuclear protein with an essential function in the Drosophila melanogaster immune deficiency pathway which responds to gram-negative bacterial infection. Akirin is conserved in vertebrates as at least two genes designated akirin1 and akirin2. In mice, akirin2 functions in toll-lie receptor, tumor necrosis factor, and interleukin-1beta signaling pathways downstream of NF-kappaB to induce the transcription of several immune-response genes. In mice, knockout of akirin1 had no obvious phenotypic effects, but knockout of akirin2 was embryonic-lethal.