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Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody – Library Pack (138101)

Host Quantity Applications Species Reactivity Data Sheet  
Mouse 4 x 100ug ELISA Human
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SKU: 138101 Categories: , , ,
Overview
Product Name Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Library Pack (138101)
Description Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody Library Pack - Includes 100 ug of each of the following antibodies:

13801 - Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Clone 1AC10-109.5 - Isotype IgG2a

13802 - Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Clone 1AC10-118.2 - Isotype IgG1

13803 - Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Clone 1AC10-128.1 - Isotype IgG1

13804 - Anti-α-1-antichymotrypsin Mouse Monoclonal Antibody - Clone 1AC10-143.1 - Isotype IgG2a

Target α-1-antichymotrypsin
Species Reactivity Human
Applications ELISA
Host Mouse
Clonality Monoclonal
Clone ID 1AC10-109.5, 1AC10-118.2, 1AC10-128.1, 1AC10-143.1
Immunogen Purified human serum alpha-1-antichymotrypsin.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by Protein G affinity chromatography
Specificity Information
Specificity These antibodies specifically recognize human serum alpha-1-antichymotrypsin. They do not cross-react with alpha-1-antitrypsin.
Target Name α-1-antichymotrypsin
Target ID α-1-antichymotrypsin
Uniprot ID P01011
Gene Name SERPINA3
Sequence Location Secreted.
Biological Function Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. {PubMed:2404007}.
Research Areas Enzymes
Background Alpha 1-antichymotrypsin (alpha1AC) is an alpha globulin glycoprotein produced in the liver that is a member of the serpin superfamily. In humans, it is encoded by the SERPINA3 gene. alpha1AC inhibits the activity of proteases such as cathepsin G from neutrophils and chymases from mast cells by cleaving them into different conformations. This activity protects tissues, such as the lower respiratory tract, from damage caused by proteolytic enzymes. alpha1AC is an acute phase protein that is induced during inflammation. Deficiency of this protein has been associated with liver disease, and mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. It is also associated with the pathogenesis of Alzheimer's disease as it enhances the formation of amyloid-fibrils.
Application Images
Additional Information
Handling
Storage These antibodies are stable for at least one (1) year at -20°C to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions These antibodies have been qualified for use in ELISA to detect human a1AC.

End users should determine optimal concentrations for their applications.
References & Data Sheet