Specificity Any Detects 90kDa Hsp90b in all reactive species except chicken where it detects both alpha and beta isoforms. This antibody detects 72 and 73kDa proteins corresponding to the predicted molecular masses of Hsp70 and Hsc70, respectively, on immunoblots of human, mouse, rat, rabbit, monkey, hamster, guinea pig, This antibody detects a 23kDa protein in human (and a 19kDa protein in other species) on SDS-PAGE immunoblots, corresponding to the molecular mass of Cu/Zn SOD. This antibody recognizes human, mouse, This antibody detects a 25kDa protein on SDS-PAGE immunoblots corresponding to the molecular mass of Mn SOD. This antibody recognizes human, monkey, mouse, rat, bovine, canine, porcine, hamster, gerb This antibody recognizes 3-nitrotyrosine moieties, species-independent. No detectable reactivity with non-nitrated tyrosine. This antibody recognizes a ~70 kDa protein corresponding to the predicted molecular mass of HDEL in Drosophila, yeast, and various plants (barnyard grass, beet, cotton, mung bean, sorghum, and wheat) This antibody recognizes a peptide backbone epitope that is common to all types of amyloid oligomers but is not found in native proteins, amyloidogenic monomers, or mature amyloid fibrils. This antibody recognizes an ~85 kDa protein (inactive form) in unstressed cell lysates and an ~95 kDa protein (active form) in heat-shocked cell lysates of human, mouse, rat, rabbit, bovine, guinea p This antibody recognizes an ~98 kDa protein corresponding to the predicted molecular mass of Grp94 on SDS-PAGE immunoblots in human, mouse, rat, rabbit, monkey, hamster, guinea pig, dog, bovine, shee This antibody recognizes an 84 kD nuclear matrix protein that was first discovered through its association with the N-terminal region of retinoblastoma protein. This antibody recognizes an epitope within aa 244-264 of human E2F-1. This antibody recognizes DMPO, DMPO-octanoic acid, DMPO-protein adducts, and DMPO-DNA adducts. It does not cross-react with non-adducted proteins or DNA. Species independent. This antibody recognizes epitopes common to many human amyloid fibrils and fibrillar oligomers but not prefibrillar oligomers or natively folded proteins. Predicted to recognize mouse and rat based o This antibody recognizes eukaryotic Hsp90alphab. This antibody recognizes full-length ATM, a 370 kD nuclear phosphoprotein, which is involved in the autooal recessive disease ataxia telangiectasia (AT). ATM belongs to a novel family of proteins ass This antibody recognizes full-length BRCA1, a 220 kD nuclear phosphoprotein. In a high proportion of breast and ovarian cancer cell lines, BRCA1 aberrantly mislocates to the cytoplasm. Its usefulness This antibody recognizes HSF2 in heat- shocked cell lysates of human, mouse, rat, rabbit, bovine, canine, porcine, guinea pig, hamster, sheep, and monkey. This antibody recognizes Hsp70 of human, mouse, rat, rabbit, monkey, guinea pig, hamster, chicken, bovine, canine, ovine, porcine, fish, Drosophila, and C. elegans and does not cross-react with Hsc70 This antibody recognizes human and mouse Alpha-2C adrenergic receptor. This antibody recognizes human and mouse BDNF. This antibody recognizes human and mouse BNIP3. This antibody recognizes human and mouse choline acetyltransferase. This antibody recognizes human and mouse GABARAP. This antibody recognizes human and mouse Id3. This antibody recognizes human and mouse RbAp48 and RbAp46. This antibody recognizes human and mouse RbAp48. This antibody recognizes human and mouse RPA32. RPA (Replication Protein A) is a single-stranded DNA binding protein. Human RPA is a heterotrimeric protein containing subunits of 70, 32, and 14 kD. T This antibody recognizes human and rat ATF4. This antibody recognizes human and rat Atg4C. This antibody recognizes human and rat Beclin 1. This antibody recognizes human and rat Beclin 2. This antibody recognizes human and rat LRRK2. This antibody recognizes human and rat UVRAG. This antibody recognizes human Atg12. This antibody recognizes human Atg13. This antibody recognizes human Atg2A. This antibody recognizes human Atg4D. This antibody recognizes human Atg5. This antibody recognizes human Beclin 1. This antibody recognizes human beta-actin. This antibody recognizes human CD74. This antibody recognizes human Cdc34. This antibody recognizes human DNA Ligase I (125 kD), one of the four ligase proteins found in mammalian cells that are required for the joining of DNA strand breaks that occur during DNA replication This antibody recognizes human EAAC1. This antibody recognizes human EndoPDI. This antibody recognizes human ER-b, a novel receptor (approx. 52 kD) recently isolated from testis. The size and structure of ER-b are very similar to ER-alpha with the ligand and DNA binding domain This antibody recognizes human FEN-1. This antibody recognizes human FKHR/FOX01. This antibody recognizes human GABARAPL1. This antibody recognizes human p53. This antibody recognizes human Rad50, a 153 kD protein involved in DNA double strand break repair. Rad50 is associated with Mre11 and p95 (Nibrin) to form a multiprotein complex. Following DNA damage This antibody recognizes human Rad51, a 37 kD protein that interacts with BRCA1. This interaction is important for tumor suppression. BRCA2 and Rad51 have also been shown to interact via the BRC repe This antibody recognizes human SMRT. This antibody recognizes human TRAP1. Other species have not been investigated. This antibody recognizes human Trip230, a 230 kD protein. The gene for Trip230 is located on chromosome 14q31 in a region associated with genetic alterations and thyroid hormone response abnormalitie This antibody recognizes human, monkey, mouse, rat, hamster, bovine, ovine, porcine, canine, guinea pig, and Xenopus PDI. This antibody recognizes human, mouse (weak), and rat Shank2. It does not cross- react with Shank1 or Shank3. This antibody recognizes human, mouse and rat AMIGO-1. It does not cross- react with AMIGO-2 or AMIGO-3. This antibody recognizes human, mouse and rat Dicer. This antibody recognizes human, mouse and rat GFAP. It cross-reacts with GFAP- R416W and other GFAP mutant proteins. This antibody recognizes human, mouse and rat GIT1. It does not cross-react with GIT2. This antibody recognizes human, mouse and rat KCC2. This antibody recognizes human, mouse and rat KCNQ1. This antibody recognizes human, mouse and rat KCNQ4. This antibody recognizes human, mouse and rat LRRK2. This antibody recognizes human, mouse and rat Neuroligin-3. It does not cross- react with Neuroligin-1, -2, or -4. This antibody recognizes human, mouse and rat NIS.Immunohistochemistry: use at 1-10ug/ml. Positive control: Graves disease-thyroid tissue.These are recommended concentrations; enduser should determin This antibody recognizes human, mouse and rat VDAC1. It does not cross-react with VDAC2 or VDAC3 (based on evaluation in knock-out mice). This antibody recognizes human, mouse, and chicken DNA Ligase III. Cellular localization is nuclear and mitochondrial. This antibody recognizes human, mouse, and rabbit LAMP2 (~100-110 kDa).Accession no.: NP_001017959.1 Gene ID: 16784 This antibody recognizes human, mouse, and rat Alpha 1 GABA-A receptor. It does not cross-react with Alpha 2 or Alpha 3 GABA-A receptors. This antibody recognizes human, mouse, and rat Ankyrin-B. This antibody recognizes human, mouse, and rat Ankyrin-G. This antibody recognizes human, mouse, and rat Ataxin-1. This antibody recognizes human, mouse, and rat Beta 3 GABA-A receptor. It does not cross-react with Beta 1 or 2 GABA-A receptor. This antibody recognizes human, mouse, and rat Cav3.1. It does not cross-react with Cav3.2. This antibody recognizes human, mouse, and rat Cav3.2. It does not cross-react with Cav1.3. This antibody recognizes human, mouse, and rat Cavb2. It does not cross-react with Cav b1, Cav b3, or Cav b4. This antibody recognizes human, mouse, and rat Clcn3. It does not cross-react with Clcn4 or Clcn5. This antibody recognizes human, mouse, and rat Copper-Transporting ATPase1.Immunohistochemistry: use at 1-5ug/ml. These are recommended concentrations.Enduser should determine optimal concentrations This antibody recognizes human, mouse, and rat Copper-Transporting ATPase2. This antibody recognizes human, mouse, and rat FGF13. This antibody recognizes human, mouse, and rat GABA(B)R1. It does not cross- react with GABA(B)R2. This antibody recognizes human, mouse, and rat GABA(B)R2. It does not cross- react with GABA(B)R1. This antibody recognizes human, mouse, and rat GFAP. This antibody recognizes human, mouse, and rat GluN2A/NR2A. It does not cross- react with NR2B. This antibody recognizes human, mouse, and rat HCN4. It does not cross-react with other HCNs. This antibody recognizes human, mouse, and rat LGI1. This antibody recognizes human, mouse, and rat mGluR1 and mGluR5. This antibody recognizes human, mouse, and rat mGluR1/5. This antibody recognizes human, mouse, and rat Mitofusin-2. It does not cross- react with Mitofusin-1. This antibody recognizes human, mouse, and rat MMP 9. This antibody recognizes human, mouse, and rat Mre11. This antibody recognizes human, mouse, and rat Nav1.7. It does not cross-react with other Nav channels. This antibody recognizes human, mouse, and rat Neuroligin-1. It does not cross- react with other Neuroligins. This antibody recognizes human, mouse, and rat NR1. This antibody recognizes human, mouse, and rat NRCAM. This antibody recognizes human, mouse, and rat PCDHG-A, B, and C proteins This antibody recognizes human, mouse, and rat PINK1. This antibody recognizes human, mouse, and rat PTPRF. This antibody recognizes human, mouse, and rat QKI-5. It cross-reacts with QKI-6, QKI-7, and QKI-7b. This antibody recognizes human, mouse, and rat Shank 1, 2, and 3. This antibody recognizes human, mouse, and rat SHANK1/SHANK3. This antibody recognizes human, mouse, and rat Shank3. It does not cross-react with Shank1 or Shank2. This antibody recognizes human, mouse, and rat SNAT1. This antibody recognizes human, mouse, and rat SUR1. It does not cross-react with SUR2B. This antibody recognizes human, mouse, and rat TASK1. This antibody recognizes human, mouse, and rat Tau. This antibody recognizes human, mouse, and rat TrpC7. This antibody recognizes human, mouse, and rat TrpV3. This antibody recognizes human, mouse, and rat VAChT. This antibody recognizes human, mouse, and rat VGlut2. This antibody recognizes human, mouse, and rat VGlut3. It does not cross-react with VGlut1 or VGlut2. This antibody recognizes human, mouse, bovine and chimpanzee MDC1. Specific epitope is at the N-terminus of MDC1. This antibody recognizes human, mouse, fish, rat, avian, amphibian, Drosophila, and yeast Hsp70, Hsc70, and, following heat shock, Hsp72. This antibody recognizes human, mouse, rat, and bovine HIF-1alpha. This antibody recognizes human, mouse, rat, beluga, bovine, canine, fish, guinea pig, hamster, monkey, porcine, ovine, and coral Hsp70. This antibody recognizes human, mouse, rat, bovine, canine, guinea pig, and hamster Hsp 25/27. Some cross- reactivity with alpha B crystallin. This antibody recognizes human, mouse, rat, dog, and hamster FKBP52. This antibody recognizes human, mouse, rat, fish, avian, amphibian, Drosophila, and yeast Hsp70, Hsc70, p75, and, following heat shock, Hsp72. This antibody recognizes human, mouse, rat, fish, avian, rabbit, amphibian, Drosophila, and yeast Hsp70, Hsc70, Grp78, and, following heat shock, Hsp72. This antibody recognizes human, mouse, rat, hamster, and monkey TSG101 protein. This antibody recognizes human, rat, and hamster LAMP1.Accession no.: NP_036989.1 Gene ID: 25328 This antibody recognizes human, rat, and mouse Hsp90b. It does not cross- react with Hsp90alpha. This antibody recognizes inducible and constitutive Hsp70/Hsc70 of human, mouse, rat, rabbit, monkey, guinea pig, hamster, chicken, bovine, canine, ovine, porcine, fish, Xenopus, Drosophila, C. elega This antibody recognizes inducible bovine, human, mouse and rat Hsp70. It does not cross-react with Hsc70. This antibody recognizes mitosin, a 350 kD phosphoprotein that is specifically involved in mitotic-phase progression. Mitosin is expressed throughout S, G2, and M phases of the cell cycle, but is abs This antibody recognizes mouse and rat ASIC1. It does not cross-react with ASIC2. This antibody recognizes mouse and rat Brevican. This antibody recognizes mouse and rat Delta GABA-A receptor. This antibody recognizes mouse and rat GluA1/GluR1. It does not cross-react with GluR2. This antibody recognizes mouse and rat LRP4. This antibody recognizes mouse and rat NALCN. This antibody recognizes mouse and rat Notch1. It does not cross-react with Notch2 or Notch3. This antibody recognizes mouse and rat SUR2A. It does not cross-react with SUR2B. This antibody recognizes mouse and rat Synaptotagmin-7. It does not cross- react with other Synaptotagmins. This antibody recognizes mouse and rat TARPg2, TARPg4, and TARPg8. It does not cross-react with TARPg3 This antibody recognizes mouse and rat Versican. This antibody recognizes mouse Neuroligin-4. It does not cross-react with other Neuroligins. This antibody recognizes mouse, rat, and bovine PSD95. This antibody recognizes mouse, rat, pig, and human PSD95. This antibody recognizes P. falciparum Hsp60 and cross-reacts with E.coli Hsp60/GroEl. This antibody recognizes P. falciparum Hsp70. This antibody recognizes proteins containing acetylated lysine residues. It does not react with non-acetylated lysine residues. This antibody recognizes proteins containing acetylated lysine residues. It does not recognize non-acetylated proteins. This antibody recognizes proteins containing methylated lysine residues. It does not recognize non-methylated proteins. This antibody recognizes the 95 kD nibrin protein which contains a forkhead-associated domain that is adjacent to BRCT, a breast cancer C- terminal domain involved in protein- protein interactions. p This antibody recognizes the C-terminal aa TETSQVAPA(COOH) of native and recombinant vertebrate rhodopsin. This antibody recognizes the N-terminus of Rhodopsin from all mammalian species tested (human, mouse, rat, bovine, porcine), and most fish, birds, and amphibians. This antibody recognizes the p37 subunit of human and yeast (S. cerevisiae) Replication Factor C (RFC). RFC is a heteropentameric protein consisting of p140, p40, p38, p37, and p36 subunits, RFC part This antibody recognizes the phosphorylated and non-phosphorylated forms of mouse, rat, and bovine CaMKII. This antibody recognizes the phosphorylated form of mouse and rat CaMKII. It does not react with non- phosphorylated CaMKII. Binds multiple linear epitopes within human alpha synuclein: 21-70 aa, 61-90 aa, and 101-140 aa, determined using Dot blot and ELISA with corresponding peptides. Detects ~14 kDa band corresponding to Binds within the 101-130 aa region of human alpha synuclein, determined using Dot blot and ELISA with corresponding peptides. Detects ~14 kDa band corresponding to Alpha synuclein. Band at ~40 kDa is Binds within the 101-140 aa region of human alpha synuclein, determined using WB and ELISA with corresponding peptides. Detects ~14 kDa band corresponding to Alpha synuclein. Does not detect truncat Binds within the 81-130 aa region of human alpha synuclein, determined using WB and ELISA with corresponding peptides. Detects ~14 kDa band corresponding to Alpha synuclein. Band at ~30 kDa is a dime Detects ~140kDa. Weak human detection. Does not cross-react with KCNT2/Slo2.1/Slick. Specific for 3,5-Dibromo-tyrosine. Does not cross-react with Nitrotyrosine. Specific for 4-Hydroxy-2-hexenal (4-HHE) and 4-Hydroxynonenal (4-HNE) modified proteins. Does not detect free 4-Hydroxy-2-hexenal (4-HHE) or 4-Hydroxynonenal (4-HNE). Does not cross-react with Acrole Specific for 4-Hydroxynonenal (4-HNE) modified proteins. Does not detect free 4-Hydroxynonenal. Does not cross-react with 4-Hydroxy-2-hexenal, Acrolein, Crotonaldehyde, Hexanoyl Lysine, Malondialdehy Specific for 6-Nitrotyrptophan modified proteins. Doss not cross-react with 7-Ketocholoesterol modified proteins. Specific for 7-ketocholesterol modified proteins. Specific for Acrolein modified proteins. Does not detect free acrolein. Does not cross-react with Crotonaldehyde, Hexanoyl Lysine, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, Malondialdehyde, or Methylgl Specific for Beta-O-Linked N-Acetylgalactosamine and Beta-O-Linked N-Acetylglucosamine modified proteins. Does not cross-react with Glucose or Galactose modified proteins. Specific for Beta-O-Linked N-Acetylglucosamine modified proteins. Does not cross-react with N-Acetylgalactosamine, Glucose, or Galactose modified proteins. Specific for citrulline residues on modified proteins. Tested using citrulline conjugated Bovine Serum Albumin (BSA). Specific for dityrosine modified proteins. Does not cross-react with 3,5-dibromotyrosine or bromotyrosine modified proteins. Specific for Hexanoyl-Lysine adduct (HEL) modified peptides and proteins. Does not detect free Hexanoyl-Lysine. Does not cross-react with Acrolein, Crotonaldehyde, 4-Hydroxy-2-hexenal, 4-Hydroxy none Specific for Malondialdehyde conjugated proteins. Does not detect free Malondialdehyde. Does not cross-react with Acrolein, Crotonaldehyde, Hexanoyl Lysine, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, or Specific for Methylglyoxal modified proteins. Does not detect free Methylglyoxal. Does not cross-react with Acrolein, Hexanoyl Lysine, Malondialdeyhde, 4-Hydroxy-2-hexenal, 4-Hydroxy nonenal, or Crot Specific for sulfated tyrosine residues on various proteins. Does not detect free Sulfotyrosine. Does not cross-react with phosphotyrosine.
