Anti-T-Cell Cytokine Receptor (TCCR) (NT) Antibody (40202)

$445.00

Host Quantity Applications Species Reactivity Data Sheet  
Rabbit 100ug ELISA,WB,IHC-P,IF Human
SKU: 40202 Categories: , ,
Overview
Product Name Anti-T-Cell Cytokine Receptor (TCCR) (NT) Antibody (40202)
Description Anti-TCCR (NT) Rabbit Polyclonal Antibody
Target T-Cell Cytokine Receptor (TCCR) (NT)
Species Reactivity Human
Applications ELISA,WB,IHC-P,IF
Host Rabbit
Clonality Polyclonal
Immunogen Peptide corresponding to aa 44-59 of human TCCR precursor.
Properties
Form Liquid
Concentration Lot Specific
Formulation PBS, pH 7.4.
Buffer Formulation Phosphate Buffered Saline
Buffer pH pH 7.4
Format Purified
Purification Purified by immunoaffinity chromatography
Specificity Information
Specificity This antibody recognizes an epitope at the N-terminus of human TCCR (T Cell Cytokine Receptor), a member of the type I cytokine receptor family. TCCR deficient mice have impaired responses of T helper cells (Th1) to protein antigens including decreased levels of IFN-g and Th1-dependent antibody production. TCCR is predominantly expressed in thymus, spleen, lymph nodes, and peripheral blood lymphocytes.
Target Name Interleukin-27 receptor subunitα
Target ID T-Cell Cytokine Receptor (TCCR) (NT)
Uniprot ID Q6UWB1
Alternative Names IL-27 receptor subunitα, IL-27R subunitα, IL-27R-α, IL-27RA, Cytokine receptor WSX-1, Cytokine receptor-like 1, Type I T-cell cytokine receptor, TCCR, ZcytoR1
Gene Name IL27RA
Sequence Location Membrane; Single-pass type I membrane protein.
Biological Function Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR (PubMed:19386761). Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms. {PubMed:14764690, PubMed:19386761}.
Research Areas Growth Factors, Cytokines, Receptors
Application Images
Description Western blot analysis of TCCR expression in human spleen tissue lysates with TCCR antibody at 1 ug/ml.
Description Immunohistochemistry of TCCR in human spleen tissue with TCCR antibody at 10 ug/mL.
Description Immunofluorescence of TCCR in A549 cells with TCCR antibody at 20 ug/mL.
Additional Information
Handling
Storage This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Dilution Instructions Dilute in PBS or medium that is identical to that used in the assay system.
Application Instructions Immunoblotting: use at 0.5-1 ug/mL. In immunoblots, a band of 70 kD is detected.

Positive control: Human spleen tissue lysate.
References & Data Sheet