Does your therapeutic antibody program require anti-Id antibodies to evaluate biodistribution, clearance, or immunogenicity? We’ll gladly discuss your requirements with you under strict confidentiality.

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Monoclonal Antibody Manufacturing

Anti-Idiotype Monoclonal Antibody
Development at QED Bioscience

Antibody-based drugs are well-established therapeutics for a variety of human diseases and particularly for cancer therapy. Monitoring the levels of therapeutic antibodies in clinical specimens requires the ability to distinguish an administered antibody from endogenous antibodies, and this has become increasingly difficult as therapeutic antibodies more closely resemble human immunoglobulins. Anti-idiotypic (anti-Id) antibodies that recognize unique idiotypic determinants on the V-regions of therapeutic antibodies are ideal for overcoming this problem, and QED will create these for you with our own proven in-house protocols.

Create hybridomas from Id-immunized mice

Frequently Asked Questions:

Q: What species of Id can be used for anti-Id development?

A: Any species of Id can be used. Ideally, the corresponding normal immunoglobulin is
available for confirmation of anti-Id specificity.

Q: What form of Id antibody should be used for immunizations?

A: Whole IgG as well as Fab or F(ab’)2 fragments can be used. The advantage to using Fab or F(ab’)2 fragments is that constant heavy chain determinants, which can induce unwanted antibody responses in immunized animals, are absent. Be sure to confirm that your Fab or F(ab’)2 fragments retain their antibody activity.

Q: What sort of protection of our proprietary Id antibody do you provide?

A: We will gladly execute Confidentiality and Material Transfer Agreements with you before you send your material to QED. We can provide these documents, or we can use yours.

Q: What does anti-Id development cost?

A: Prices vary depending on the different assays that are needed to produce anti-Id antibodies that fulfill our clients’ requirements. You can see a general price schedule here. Call your QED representative today to discuss your anti-Id project and promptly receive a customized price quote for your project.